Basic Information

Gene symbol CD19 Synonyms B4, CVID3 Type of gene protein-coding
Description CD19 molecule

GTO ID GTC0893
Trial ID ChiCTR2000040018
Disease B-Cell Malignancy
Altered gene CD19
Therapeutic/Target gene Target gene
TherapyCAR-T cell
Treatment CD19 CAR-T cells
PhasePhase1
Recruitment statusNot Recruiting
TitlePhase the Safety and Tolerability of CD19 Universal Chimeric Antigen Receptor T Cells in Subjects with R/R CD19 positive B cell malignant tumors
Year2020
CountryChina
Company sponsorThe Affiliated Hospital of Nantong University

Clinical Result

Cohort1: dose level 1
Administration route None
Dosage 0.5E6 cells/kg, 1E6 cells/kg, 2E6 cells/kg
Pts 1
Age Adult, Older_Adult
Cohort2: dose level 2
Administration route None
Dosage 2E6 cells/kg, 3E6 cells/kg, 5E6 cells/kg
Pts 1
Age Adult, Older_Adult
Cohort3: dose level 3
Administration route None
Dosage 3E6 cells/kg, 5E6 cells/kg, 7.0E6 cells/kg
Pts 1
Age Adult, Older_Adult
Cohort4: dose level 4
Administration route None
Dosage Select the above optimal dose
Pts 9
Age Adult, Older_Adult

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