Basic Information

Gene symbol CD19 Synonyms B4, CVID3 Type of gene protein-coding
Description CD19 molecule

Gene symbol MS4A1 Synonyms B1, Bp35, CD20, CVID5, FMC7, LEU-16, S7 Type of gene protein-coding
Description membrane spanning 4-domains A1

Gene symbol CD22 Synonyms SIGLEC-2, SIGLEC2 Type of gene protein-coding
Gene perturbation-related omics dataset PerturbAtlas | PertOrg
Description CD22 molecule

GTO ID GTC0844
Trial ID ChiCTR2000028826
Disease Multiple Myeloma
Altered gene CD19|CD20|CD22
Therapeutic/Target gene Target gene
TherapyCAR-T cell
Treatment CAR-T cells
PhaseEarly_Phase1
Recruitment statusRecruiting
TitleClinical study for CD20-targeting iNKT cells and anti-CD19/CD22 CAR-T cells in the treatment of refractory or relapse AIDS-related B-cell lymphoma
Year2020
CountryChina
Company sponsorShanghai Public Health Clinical Center

Clinical Result

Cohort1: CD20-targeting iNKT cells
Administration route None
Pts 10
Age Adult, Older_Adult
Cohort2: anti-CD19/CD22 CAR-T cells
Administration route None
Pts 24
Age Adult, Older_Adult
Cohort3: anti-CD19/CD22 CAR-T cells combined with HIV-specific CAR-T cells
Administration route None
Pts 10
Age Adult, Older_Adult
Cohort4: HIV-specific CAR-T cells
Administration route None
Pts 60
Age Adult, Older_Adult

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