Basic Information

Gene symbol CD19 Synonyms B4, CVID3 Type of gene protein-coding
Description CD19 molecule

Gene symbol MS4A1 Synonyms B1, Bp35, CD20, CVID5, FMC7, LEU-16, S7 Type of gene protein-coding
Description membrane spanning 4-domains A1

Gene symbol IL15 Synonyms IL-15 Type of gene protein-coding
Gene perturbation-related omics dataset PerturbAtlas
Description interleukin 15

GTO ID GTC0825
Trial ID ChiCTR1900026083
Disease B-Cell Malignancy
Altered gene CD19|CD20|IL15
Therapeutic/Target gene Target gene
TherapyCAR-T cell
Treatment ICG132|ICG134
PhaseEarly_Phase1
Recruitment statusRecruiting
TitleCD19/CD20/CARVAC-targeted Chimeric antigen receptor gene-modified T cells therapy in Patients with relapsed/refractory B cell malignancies
Year2019
CountryChina
Company sponsorThe First Affiliated Hospital of Xiamen University
Vector information
Vectorlentivirus
Additional featureIL-15

Clinical Result

Cohort1: ICG132
Administration route intravenous infusion
Dosage 1E6 cells, 2E6 cells, 4E6 cells, 8E6 cells
Pts 12
Age Child, Adult, Older_Adult
Cohort2: ICG134
Administration route intravenous infusion
Dosage 1E6 cells, 2E6 cells, 4E6 cells, 8E6 cells
Pts 12
Age Child, Adult, Older_Adult

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