Basic Information

Gene symbol CCR5 Synonyms CC-CKR-5, CCCKR5, CCR-5, CD195, CKR-5, CKR5, CMKBR5, IDDM22 Type of gene protein-coding
Gene perturbation-related omics dataset PertOrg
Description C-C motif chemokine receptor 5

GTO ID GTC0711
Trial ID ACTRN12615000763549
Disease Primary HIV-1 Infection
Altered gene CCR5
Therapeutic/Target gene Therapeutic gene
TherapyGene transfer
Treatment Cal-1
PhasePhase1|Phase2
Recruitment statusWithdrawn
TitleAn adaptive phase I/II, dose-ranging study to evaluate the safety and feasibility of busulfan conditioning prior to transplant of CD4+ T lymphocytes and CD34+ haematopoietic stem/progenitor cells (HSPCs) transduced with LVSH5/C46 (CAL-1), in adults diagnosed at primary HIV-1 infection who are established on effective combination antiretroviral therapy (ART)
Year2015
CountryAustralia|United States
Company sponsorCalimmune Australia Pty Limited
Vector information
Vectorlentivirus

Clinical Result

Cohort 1
Administration route infusion
Donor type autologous
Age Adult, Older_Adult

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