Basic Information

Gene symbol APOC3 Synonyms APOCIII, Apo-C3, ApoC-3 Type of gene protein-coding
Description apolipoprotein C3

GTO ID GTC0696
Trial ID 2021-002192-19
Disease Familial Hypercholesterolemia
Altered gene APOC3
Therapeutic/Target gene Target gene
TherapyASO
Treatment Olezarsen|ISIS 678354|IONIS-APOCIII-LRx|AKCEA-APOCIII-LRx
PhasePhase3
Recruitment statusOngoing
TitleA Randomized, Double-Blind, Placebo-Controlled, Phase 3 Study of ISIS 678354 Administered Subcutaneously to Patients with Severe Hypertriglyceridemia
Year2022
CountryAustralia|Bulgaria|Canada|Czechia|Denmark|Finland|France|Germany|Hungary|Israel|Italy|Netherlands|New Zealand|Norway|Poland|Portugal|Slovakia|South Africa|Spain|Sweden|Turkey|United Kingdom|United States
Company sponsorIonis Pharmaceuticals, Inc.
Other ID(s)NCT05079919|ISIS 678354-CS5
Vector information
VectorNo vector was used

Clinical Result

Cohort 1
Administration route subcutaneous injection
Dosage 100 mg/ml
Age Adult, Older_Adult

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