Basic Information

Gene symbol IFNA2 Synonyms IFN-alpha-2, IFN-alphaA, IFNA, IFNA2B, leIF A Type of gene protein-coding
Description interferon alpha 2

GTO ID GTC0663
Trial ID 2018-001741-14
Disease Multiple Myeloma
Altered gene IFNA2
Therapeutic/Target gene Therapeutic gene
TherapyGene transfer
Treatment IFNA2 LV CD34+ cells
PhasePhase1|Phase2
Recruitment statusPrematurely Ended
TitleA phase I/II dose escalation study evaluating safety and activity of autologous CD34+-enriched hematopoietic progenitor cells genetically modified with a lentiviral vector encoding for the human interferon-alfa2 gene in multiple myeloma patients with early relapse after intensive front line therapy
Year2018
CountryItaly
Company sponsorOSPEDALE SAN RAFFAELE
Vector information
Vectorlentivirus

Clinical Result

Cohort 1
Administration route injection
Dosage 2.5E6~1E7
Donor type autologous
Age Adult, Older_Adult

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