Basic Information

Gene symbol MAGEA4 Synonyms CT1.4, MAGE-41, MAGE-X2, MAGE4, MAGE4A, MAGE4B Type of gene protein-coding
Description MAGE family member A4

GTO ID GTC0615
Trial ID JPRN-UMIN000002395
Disease Esophageal Cancer
Altered gene MAGE-A4
Therapeutic/Target gene Target gene
TherapyTCR-T cell
Treatment MAGE-A4 TCR-T cells
PhasePhase1
Recruitment statusNot Recruiting
TitleAdoptive transfer of lymphocytes transduced with MAGE-A4-specific TCR gene for therapy-resistant esophageal cancer
Year2009
CountryJapan
Company sponsorMie University Hospital

Clinical Result

Cohort1: dose level 1
Administration route intravenous infusion
Dosage 2E8 cells
Donor type autologous
Pts 3
Age Adult, Older_Adult
Adverse reactions 1/3(Skin reaction)
References DOI: 10.1158/1078-0432.CCR-14-1559
Cohort2: dose level 2
Administration route intravenous infusion
Dosage 1E9 cells
Donor type autologous
Pts 4
Age Adult, Older_Adult
Adverse reactions 2/4(Skin reaction)
References DOI: 10.1158/1078-0432.CCR-14-1559
Cohort3: dose level 3
Administration route intravenous infusion
Dosage 5E9 cells
Donor type autologous
Pts 3
Age Adult, Older_Adult
Adverse reactions 1/3(Skin reaction)
References DOI: 10.1158/1078-0432.CCR-14-1559

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