Basic Information

Gene symbol CD19 Synonyms B4, CVID3 Type of gene protein-coding
Description CD19 molecule

GTO ID GTC0614
Trial ID JPRN-jRCT1080224971
Disease Acute Lymphoblastic Leukemia
Altered gene CD19
Therapeutic/Target gene Target gene
TherapyCAR-T cell
Treatment UCAR-T19
PhasePhase1
Recruitment statusNot Recruiting
TitleDose Escalation Study of UCART19 in Adult Patients With Relapsed / Refractory B-cell Acute Lymphoblastic Leukaemia
Year2019
CountryNorth America|Japan
Company sponsorNihon Servier
Other ID(s)NCT02746952

Clinical Result

Cohort 1
Administration route None
Dosage 1E6 cells/kg, 3E6 cells/kg
Donor type Allogeneic
Pts 30
Age Adult, Older_Adult
Outcome 48.0%(ORR),75.0%(MRD negative rate)
Adverse reactions 92.0% of patients reported at least one severe EAE(grade ≥ 3 according to CTCAE); 56.0%(mainly anaemia); 32.0%(thrombocytopenia); 28.0%(febrile neutropenia)

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