Basic Information

Gene symbol CTAG1B Synonyms CTAG, ESO1, CT6.1, CTAG1, LAGE-2, LAGE2B, NY-ESO-1 Type of gene protein-coding
Description cancer/testis antigen 1B

GTO ID GTC0613
Trial ID JMA-IIA00346
Disease Synovial Sarcoma
Altered gene NY-ESO-1
Therapeutic/Target gene Target gene
TherapyTCR-T cell
Treatment NY-ESO-1 TCR-T cells
HLAHLA-A*02:01|HLA-A*02:06
PhasePhase1
Recruitment statusCompleted
TitleInvestigator-initiated multi-institutional clinical trial of combination therapy of vaccination and gene-modified T cell targeting NY-ESO-1-antigen for refractory soft tissue sarcoma
Year2018
CountryJapan
Company sponsorMie University Hospital
Vector information
Vectorretrovirus
ConstructpMS3-NY-ESO-1-siTCR
Transgene/Inserted geneDNA encoding TCR-α and TCR-β chains specific for NY-ESO-1157-165 and HLA-A*02:01 (MS3-NY-ESO-1-siTCR); interfering RNA constructs that specifically downregulate endogenous TCR

Clinical Result

Cohort 1
Administration route infusion
Dosage 5E9 cells
Donor type autologous
Pts 3
Lymph depletion No
Outcome 1/3(PR)
Adverse reactions 2(CRS)
References PMID: 36727538

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