Basic Information

Gene symbol WT1 Synonyms AWT1, GUD, NPHS4, WAGR, WIT-2, WT-1, WT33 Type of gene protein-coding
Gene perturbation-related omics dataset PerturbAtlas | PertOrg
Description WT1 transcription factor

GTO ID GTC0612
Trial ID ISRCTN11622375
Disease Myeloid Leukemia
Altered gene WT1
Therapeutic/Target gene Target gene
TherapyTCR-T cell
Treatment WT1 TCR-T cells
HLAHLA-A*02:01
PhasePhase1|Phase2
Recruitment statusCompleted
TitleA phase I/II safety and toxicity study on the use of WT1 TCR gene therapy for adult patients with acute and chronic myeloid leukaemia
Year2010
CountryUnited Kingdom
Company sponsorUniversity College London (UCL) (UK)
Other ID(s)2006-004950-25|NCT01621724|D-00272-CT2014001
Vector information
Vectorretrovirus

Clinical Result

Cohort1: dose level 1
Administration route intravenous infusion
Dosage 2E7 cells/kg
Donor type autologous
Pts 3
Age Adult, Older_Adult
Lymph depletion Yes
Outcome 1/3(CR); 2/3(NR). 3 patients had No dose-limiting toxicity.
Adverse reactions 2/3(Blood and lymphatic system disorders)
Cohort2: dose level 2
Administration route intravenous infusion
Dosage 1E8 cells/kg
Donor type autologous
Pts 4
Age Adult, Older_Adult
Lymph depletion Yes
Outcome 3/4(CR); 1/4(NR). 3 patients had No dose-limiting toxicity.
Adverse reactions No serious clinical adverse events

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