Basic Information

Gene symbol CD19 Synonyms B4, CVID3 Type of gene protein-coding
Description CD19 molecule

GTO ID GTC0611
Trial ID ChiCTR2000031868
Disease B-Cell Lymphoma
Altered gene CD19
Therapeutic/Target gene Target gene
TherapyCAR-T cell
Treatment CD19 CAR-T cells
Generation2nd
PhaseEarly_Phase1
Recruitment statusRecruiting
TitleStudy Evaluating the Efficacy and Safety of Chimeric Antigen Receptor Engineered T cells in CD19 Positive Relapsed or Refractory Leukemia and Lymphoma
Year2020
CountryChina
Company sponsorThe First Affiliated Hospital of USTC (Anhui Provincial Hospital)

Clinical Result

Cohort 1
Administration route None
Dosage 0.1~1.3E8 cells
Pts 18
Age Child, Adult, Older_Adult
Outcome 90% (9/10) patients with ALL, 40% (2/5) with Lymphoma, and 100% (2/2) patients with MM achieved CR, while 40% (2/5) with Lymphoma achieved PR
Adverse reactions Patients did not show neurotoxicity during CRS and exhibited mild to moderate CRS.
References PMID: 34518515

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