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Basic Information Clinical Results Relationship Graph

Basic Information

Gene symbol	TNFRSF17	Synonyms	BCM, BCMA, CD269, TNFRSF13A	Type of gene	protein-coding
Chromosome	16	Map location	16p13.13	dbXrefs
Description	TNF receptor superfamily member 17

Gene symbol	CD38	Synonyms	ADPRC 1, ADPRC1, cADPR1	Type of gene	protein-coding
Chromosome	4	Map location	4p15.32	dbXrefs
Gene perturbation-related omics dataset	PertOrg
Description	CD38 molecule

GTO ID	GTC0609
Trial ID	ChiCTR1900026286
Disease	Multiple Myeloma
Altered gene	BCMA\|CD38
Therapeutic/Target gene	Target gene
Therapy	CAR-T cell
Treatment	BCMA/CD38 CAR-T cells
Phase	Phase1
Recruitment status	Recruiting
Title	Clinical Study for the Efficacy and Safety of BCMA-CD38 Bispecific CAR-T cells in Relapsed and Refractory Multiply Myeloma
Year	2019
Country	China
Company sponsor	The Second Clinical Medical College, Yangtze University, Jingzhou Central Hospital

Vector information

Vector	lentivirus
Vector type	third generation lentiviral cytoskeleton vector
Transgene/Inserted gene	CAR fusion gene
Viral genome modification	The CAR fusion gene was inserted into third generation lentiviral cytoskeleton vector pLVX-EF1.
Vector production method	PLVX-EF1 with CAR fusion gene, the helper plasmid and lentivirus packaging were co-transfected into HEK-293 T cells.

Clinical Result

Cohort 1

Administration route	None
Dosage	0.5~10E6 cells/kg
Pts	16
Age	Adult, Older_Adult
Outcome	13/16(CR); 1/16(PR).1-year progression-free survival rate:68.8%; 1-year overall survival rate:75.0%
Adverse reactions	5/16(Grade ≥3 CRS)
References	PMID: 34980210

Relationship Graph

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