Basic Information

Gene symbol TNFRSF17 Synonyms BCM, BCMA, CD269, TNFRSF13A Type of gene protein-coding
Description TNF receptor superfamily member 17

GTO ID GTC0608
Trial ID ChiCTR1900026219
Disease Multiple Myeloma
Altered gene BCMA
Therapeutic/Target gene Target gene
TherapyCAR-T cell
Treatment BCMA CAR-T cells
PhaseEarly_Phase1
Recruitment statusRecruiting
TitleCombination of humanized anti-CD19 CAR-T and anti-BCMA CAR-T versus anti-BCMA CAR-T alone for relapsed or refractory multiple myeloma:a multicenter, open-label, randomized controlled trial
Year2019
Countrychina
Company sponsorThe Affiliated Hospital of Xuzhou Medical University

Clinical Result

Cohort1: GC
Administration route None
Pts 31
Age Adult, Older_Adult
Lymph depletion Yes
Outcome 64.5%(CR); 93.5(ORR)
Adverse reactions 7/31(Grade ≥3 CRS); 2/31(Grade ≥3 ICANS)
References PMID: 36081517
Cohort2: no GC
Administration route None
Pts 40
Age Adult, Older_Adult
Lymph depletion Yes
Outcome 57.5%(CR); 85%(ORR)
Adverse reactions no Grade ≥3 CRS
References PMID: 36081517

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