Basic Information

Gene symbol CD19 Synonyms B4, CVID3 Type of gene protein-coding
Description CD19 molecule

Gene symbol CD22 Synonyms SIGLEC-2, SIGLEC2 Type of gene protein-coding
Gene perturbation-related omics dataset PerturbAtlas | PertOrg
Description CD22 molecule

GTO ID GTC0603
Trial ID ChiCTR1900023922
Disease B-Cell Malignancy
Altered gene CD19|CD22
Therapeutic/Target gene Target gene
TherapyCAR-T cell
Treatment CD19/CD22 CAR-T cells
PhaseEarly_Phase1
Recruitment statusRecruiting
TitleAn open-label, single-center and single-arm clinical study of infusion of anti-CD19 or CD22 CAR-T cells (CT101A-19 or CT102A-22) for patients with relapsed/refractory/high risk B cell malignancies.
Year2019
CountryChina
Company sponsorTongji Hospital, Tongji Medical College, Huazhong University of Science and Technology

Clinical Result

Cohort 1
Administration route None
Pts 1
Age Adult, Older_Adult
Outcome 100%(CR), 100%(ORR)
Adverse reactions Grade 4 and grade 1 cytokine release syndrome occurred after the first and second rounds of CAR T-cell therapy, respectively.
References PMID: 32345625

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