Basic Information

Gene symbol CD19 Synonyms B4, CVID3 Type of gene protein-coding
Description CD19 molecule

GTO ID GTC0602
Trial ID ChiCTR1900023212
Disease Acute Lymphoblastic Leukemia
Altered gene CD19
Therapeutic/Target gene Target gene
TherapyCAR-T cell
Treatment GC007F|Fast-CAR-T cells
Generation2nd
PhasePhase1
Recruitment statusNot Recruiting
TitleStudy for the role of Fast-CAR-T in the treatment of refractory/relapsed CD19+ acute lymphoblastic leukemia
Year2019
CountryChina
Company sponsorXinqiao Hospital, Army Medical University
Vector information
Vectorlentivirus
Transgene/Inserted geneFMC63 anti-CD19 single-chain variable fragment (scFv); CD8α hinge region; CD8α transmembrane domain; CD28 costimulatory domain; CD3ζ activation domain
Additional featureFLAG tag (DYKDDDDK)

Clinical Result

Cohort 1
Administration route None
Dosage 0.5 E5 cells/kg, 1E5 cells/kg, 1.5E5 cells/kg
Pts 18
Age Child, Adult, Older_Adult
Outcome 17/18(CR); 15/18 remained disease free at the 3-month assessment, 14/18 maintaining MRD negative at month 3.
Adverse reactions 11/18(severe CRS); 6/18(neurotoxicity)
References PMID: 35750687

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