Basic Information

Gene symbol GCGR Synonyms GGR, GL-R, MVAH Type of gene protein-coding
Gene perturbation-related omics dataset PerturbAtlas | PertOrg
Description glucagon receptor

GTO ID GTC0584
Trial ID 2015-003337-10
Disease Type 2 Diabetes Mellitus
Altered gene GCGR
Therapeutic/Target gene Target gene
TherapyASO
Treatment ISIS 449884|ISIS-GCGRRX
PhasePhase2
Recruitment statusCompleted
TitleA Double Blind, Placebo-Controlled, Phase 2A Mechanistic Study to Evaluate the Effect of ISIS 449884 (ISIS-GCGRRX an Antisense Inhibitor of the Glucagon Receptor) on Hepatic Lipid and Glycogen Content in Patients with Type 2 Diabetes Being Treated with Metformin
Year2015
CountryHungary
Company sponsorIonis Pharmaceuticals, Inc.
Other ID(s)NCT02824003
Vector information
VectorNo vector was used

Clinical Result

Cohort 1
Administration route subcutaneous injection
Dosage 100 mg
Pts 8
Age Adult, Older_Adult
Outcome Arithmetic mean (standard deviation) of change from baseline in fasting hepatic glycogen content (HGC) is 23.66 ( 24.57 ) mmol/L from baseline to Week 6, 15.11 ( 39.30 ) mmol/L from baseline to Week 14.
Adverse reactions No serious clinical adverse events
References PMID: 30765435

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