Basic Information

Gene symbol CLU Synonyms AAG4, APO-J, APOJ, CLI, CLU1, CLU2, KUB1, NA1/NA2, SGP-2, SGP2, SP-40, TRPM-2, TRPM2 Type of gene protein-coding
Description clusterin

GTO ID GTC0577
Trial ID 2012-002447-14
Disease Lung Non-Small Cell Carcinoma
Altered gene CLU
Therapeutic/Target gene Target gene
TherapyASO
Treatment OGX-011|custirsen sodium|TV-1011
PhasePhase3
Recruitment statusPrematurely Ended
TitleA Multinational, Randomized, Open-Label Phase III Study of Custirsen (TV-1011/OGX-011) In Combination With Docetaxel Versus Docetaxel As A Second-Line Treatment In Patients With Advanced or Metastatic (Stage IV) Non-Small Cell Lung Cancer
Year2012
CountryAustralia|Germany|Hungary|Israel|Italy|Korea,Republic of|New Zealand|Poland|Russian Federation|Singapore|Spain|China|Thailand|Ukraine|United States
Company sponsorOncoGenex Technologies Inc
Other ID(s)NCT01630733
Vector information
VectorNo vector was used

Clinical Result

Cohort 1
Administration route intravenous infusion
Dosage 640 mg
Pts 332
Age Adult, Older_Adult
Adverse reactions 113/332(Neoplasms benign, malignant and unspecified, incl cysts and polyps; Vascular disorders; General disorders and administration site conditions; Respiratory, thoracic and mediastinal disorders; Psychiatric disorders; Injury, poisoning and procedural complications; Cardiac disorders; Nervous system disorders; Blood and lymphatic system disorders; Gastrointestinal disorders; Hepatobiliary disorders; Renal and urinary disorders; Musculoskeletal and connective tissue disorders; Infections and infestations; Metabolism and nutrition disorders)

Relationship Graph

Overview of Knowledge Graph