| Vector | retrovirus |
| Transgene/Inserted gene | DNA encoding MAGE-A4143-151/HLA-A*24:02-specific TCR-α and -β chains |
| Vector production method | Lymphocytes were collected from each patient by processing 5 L of peripheral blood by apheresis. In the cell-processing facility, the lymphocytes were cultured with IL2, anti-CD3 antibody, and RetroNectin (Takara Bio Inc.) under institutional GMP control. Proliferating lymphocytes were infected with the retroviral vector, MS-bPa.After 7-10 days in culture, the lymphocytes were harvested and then frozen until use. |
|