Basic Information

Gene symbol EGFR Synonyms ERBB, ERRP, HER1, mENA, ERBB1, PIG61, NISBD2 Type of gene protein-coding
Gene perturbation-related omics dataset PerturbAtlas | PertOrg
Description epidermal growth factor receptor

GTO ID GTC0568
Trial ID NCT05660369
Disease Malignant Glioma | Glioblastoma
Altered gene EGFR
Therapeutic/Target gene Target gene
TherapyCAR-T cell
Treatment CARv3-TEAM-E
PhasePhase1
Recruitment statusRecruiting
TitleCARv3-TEAM-E T Cells in Glioblastoma
Year2022
CountryUnited States
Company sponsorMarcela V. Maus, M.D., Ph.D.
Other ID(s)22-175
Vector information
Vectorlentivirus

Clinical Result

Cohort 1
Administration route None
Donor type Autologous
Pts 21
Age Adult, Older_Adult
Outcome Radiographic tumor regression was dramatic and rapid, occurring within days after receipt of a single intraventricular infusion, but the responses were transient in two of the three participants.
Adverse reactions no any CAR-T-related severe events
References PMID: 38477966

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