Basic Information

Gene symbol S Synonyms E2 Type of gene protein-coding
Gene perturbation-related omics dataset PerturbAtlas
Description spike glycoprotein

GTO ID GTC0560
Trial ID NCT05060354
Disease Multiple Sclerosis
Altered gene S
Therapeutic/Target gene Therapeutic gene
TherapymRNA vaccine
Co-treatment ocrelizumab
Recruitment statusRecruiting
TitleImmune Response to SARS-CoV2 Vaccinations in Treated MS Patients Compared to Controls
Year2021
CountryUnited States
Company sponsorBrigham and Women's Hospital
Other ID(s)COMB157GUS19T
Vector information
Vectorlipid nanoparticle

Clinical Result

Cohort1: Ocrelizumab patients after 2nd vaccine
Administration route None
Pts 33
Age Adult, Older_Adult
Outcome percentage of MS patients on immunotherapy with a positive SARS-CoV-2 Spike antibody response: 8/33 (24.2%)
References PMID: 37057191
Cohort2: Ocrelizumab patients after 3rd vaccination
Administration route None
Pts 22
Age Adult, Older_Adult
Outcome percentage of MS patients on immunotherapy with a positive SARS-CoV-2 Spike antibody response: 9/22(40.9%)
References PMID: 37057191
Cohort3: Fingolimod patients after 2nd vaccin
Administration route None
Pts 7
Age Adult, Older_Adult
Outcome percentage of MS patients on immunotherapy with a positive SARS-CoV-2 Spike antibody response: 5/7 (71.4%)
References PMID: 37057191
Cohort4: Fingolimod patients after 3rd vaccine
Administration route None
Pts 21
Age Adult, Older_Adult
Outcome percentage of MS patients on immunotherapy with a positive SARS-CoV-2 Spike antibody response: 19/21 (90.5%)
References PMID: 37057191
Cohort5: Healthy controls after 2nd vaccine
Administration route None
Pts 29
Age Adult, Older_Adult
Outcome percentage of MS patients on immunotherapy with a positive SARS-CoV-2 Spike antibody response: 29/29 (100%)
References PMID: 37057191
Cohort6: Healthy controls after 3rd vaccine
Administration route None
Pts 7
Age Adult, Older_Adult
Outcome percentage of MS patients on immunotherapy with a positive SARS-CoV-2 Spike antibody response: 7/7 (100%)
References PMID: 37057191

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