Detail

Basic Information Clinical Results Relationship Graph

Basic Information

Gene symbol	S	Synonyms	E2	Type of gene	protein-coding
Chromosome	-	Map location	NC_004718.3 (21492..25259)	dbXrefs
Gene perturbation-related omics dataset	PerturbAtlas
Description	spike glycoprotein

GTO ID	GTC0556
Trial ID	NCT04969276
Disease	Influenza
Altered gene	S
Therapeutic/Target gene	Therapeutic gene
Therapy	mRNA vaccine
Treatment	mRNA-1273\|Elasomeran\|Spikevax
Co-treatment	Quadrivalent Inactivated Influenza High Dose
Location approved	UK, Canada, Taiwan, Switzerland, Japan, EU, Australia, South Korea, Singapore, US
Phase	Phase2
Recruitment status	Completed
Title	A Phase II, Open-label Study to Assess the Safety and Immunogenicity of Fluzone High-Dose Quadrivalent (Influenza Vaccine), 2021-2022 Formulation and a Third Dose of Moderna COVID-19 Vaccine (mRNA-1273 Vaccine) Administered Either Concomitantly or Singly in Adults 65 Years of Age and Older Previously Vaccinated With a 2-dose Schedule of Moderna COVID-19 Vaccine
Year	2021
Country	United States
Company sponsor	Sanofi Pasteur, a Sanofi Company
Other ID(s)	QHD00028\|U1111-1266-7472

Vector information

Vector	lipid nanoparticle

Clinical Result

Cohort1: Fluzone HD Quadrivalent vaccine_mRNA-1273

Administration route	intramuscular injection
Dosage	fluzone HD quadrivalent influenza vaccine, 0.7 mL; COVID-19 vaccine, 0.5 mL
Pts	100
Age	Child, Adult
Adverse reactions	0/100(All-cause mortality); 2/100(Cardiac disorders; Neoplasms benign, malignant and unspecified(incl cysts and polyps))
References	PMID: 35114141

Cohort2: Fluzone HD Quadrivalent vaccine

Administration route	intramuscular injection
Dosage	fluzone HD quadrivalent influenza vaccine, 0.7 mL
Pts	92
Age	Child, Adult
Adverse reactions	No serious clinical adverse events
References	PMID: 35114141

Cohort3: mRNA-1273

Administration route	intramuscular injection
Dosage	COVID-19 vaccine, 0.5 mL
Pts	104
Age	Child, Adult
Adverse reactions	0/104(All-cause mortality); 3/104(Endocrine disorders; Gastrointestinal disorders; Injury, poisoning and procedural complications; Musculoskeletal and connective tissue disorders)
References	PMID: 35114141

Relationship Graph

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