Basic Information

Gene symbol S Synonyms E2 Type of gene protein-coding
Gene perturbation-related omics dataset PerturbAtlas
Description spike glycoprotein

GTO ID GTC0544
Trial ID NCT04761822
Disease COVID-19
Altered gene S
Therapeutic/Target gene Therapeutic gene
TherapymRNA vaccine
Treatment Moderna COVID-19 Vaccine
Location approved US, Canada, Israel, EU, Switzerland, Singapore, Qatar, Vietnam, UK, Philippines, Thailand, Japan, South Korea, Brunei, Paraguay, China, Botswana, India, Indonesia, Saudi Arabia, Mexico, Australia, Nigeria, Colombia
PhasePhase2
Recruitment statusCompleted
TitleSystemic Allergic Reactions to SARS-CoV-2 Vaccination
Year2021
CountryUnited States
Company sponsorNational Institute of Allergy and Infectious Diseases (NIAID)
Other ID(s)DAIT COVID-19-004|NIAID CRMS ID#: 38814
Vector information
Vectorlipid nanoparticle

Clinical Result

Cohort1: BNT162b2
Administration route intramuscular injection
Dosage BNT162b2, 0.5 mL, two doses, 1 month (28 days) apart
Pts 227
Age Child, Adult, Older_Adult
Adverse reactions 0/227(All-cause mortality); 5/227(Cardiac disorders; Immune system disorders; Injury, poisoning and procedural complications; Vascular disorders)
Cohort2: mRNA-1273
Administration route intramuscular injection
Dosage mRNA-1273, 0.5 mL, two doses, 1 month (28 days) apart
Pts 117
Age Child, Adult, Older_Adult
Adverse reactions 0/219(All-cause mortality); 2/219(Immune system disorders; Injury, poisoning and procedural complications; Metabolism and nutrition disorders; Musculoskeletal and connective tissue disorders)
Cohort3: Placebo_BNT162b2
Administration route intramuscular injection
Dosage BNT162b2, 0.3 mL, two doses, 3 weeks (21 days) apart
Pts 123
Age Child, Adult, Older_Adult
Adverse reactions 0/123(All-cause mortality); 3/123(Immune system disorders; Nervous system disorders; Renal and urinary disorders）
Cohort4: Placebo_mRNA-1273
Administration route intramuscular injection
Dosage mRNA-1273, 0.5 mL, two doses, 3 weeks (21 days) apart
Pts 219
Age Child, Adult, Older_Adult
Adverse reactions 0/117(All-cause mortality); 2/117(Immune system disorders; Infections and infestations)

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