Basic Information

Gene symbol CD7 Synonyms GP40, LEU-9, TP41, Tp40 Type of gene protein-coding
Description CD7 molecule

GTO ID GTC0541
Trial ID NCT04689659
Disease T-Cell Lymphoblastic Leukemia
Altered gene CD7
Therapeutic/Target gene Target gene
TherapyCAR-T cell
Treatment CD7 CAR-T cells
PhasePhase2
Recruitment statusRecruiting
TitleMulti-centers, Open-Label, Phase 2 Study to Evaluate the Efficacy and Safety of Donor-Derived CD7 CAR T Cells in Subjects With Relapsed or Refractory T-cell Leukemia/Lymphoma
Year2020
CountryChina
Company sponsorBeijing Boren Hospital
Other ID(s)BR-IIT-LCYJ-2020-005

Clinical Result

Cohort 1
Administration route intravenous infusion
Dosage 5E5 cells/kg, 1E6 cells/kg
Donor type Allogeneic
Pts 20
Age Child, Adult, Older_Adult
Outcome 18/20(CR); 100%(CRS),90%(Grade 1-2),5%(grade 3),5%(grade 4)
Adverse reactions 10%(Grade 3/4 cytokine release syndrome); 100%(Grade 3/4 cytopenia)
References PMID: 34324392

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