Basic Information

Gene symbol CD19 Synonyms B4, CVID3 Type of gene protein-coding
Description CD19 molecule

GTO ID GTC0540
Trial ID NCT04684563
Disease Diffuse Large B-Cell Lymphoma | Follicular Lymphoma | Large B-Cell Lymphoma | Chronic Lymphocytic Leukemia | B-Cell Lymphoma
Altered gene CD19
Therapeutic/Target gene Target gene
TherapyCAR-T cell
Treatment CD19 CAR-T cells-IL18
Generation4th
PhasePhase1
Recruitment statusRecruiting
TitleHuCART19-IL18 in CD19+ Cancers
Year2020
CountryUnited States
Company sponsorUniversity of Pennsylvania
Other ID(s)UPCC15420; IRB# 844955
Vector information
Vectorlentivirus
Additional featureIL-18

Clinical Result

Cohort1: dose level 1_no lymphodepleting
Administration route intravenous infusion
Dosage 3E6 cells
Donor type Autologous
Pts 1
Age Adult, Older_Adult
Lymph depletion No
Outcome 1/1(CR)
References DOI: 10.1182/blood-2022-162393
Cohort2: dose level 1_lymphodepleting
Administration route intravenous infusion
Dosage 3E6 cells
Donor type Autologous
Pts 2
Age Adult, Older_Adult
Lymph depletion Yes
Outcome 2/2(CR)
References DOI: 10.1182/blood-2022-162393
Cohort3: dose level 2_lymphodepleting
Administration route intravenous infusion
Dosage 7E6 cells
Donor type Autologous
Pts 1
Age Adult, Older_Adult
Lymph depletion Yes
References DOI: 10.1182/blood-2022-162393
Cohort4: dose level 3_lymphodepleting
Administration route intravenous infusion
Dosage 3E7 cells
Donor type Autologous
Pts 2
Age Adult, Older_Adult
Lymph depletion Yes
References DOI: 10.1182/blood-2022-162393

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