Basic Information

Gene symbol S Synonyms E2 Type of gene protein-coding
Gene perturbation-related omics dataset PerturbAtlas
Description spike glycoprotein

GTO ID GTC0538
Trial ID NCT04652102
Disease COVID-19
Altered gene S
Therapeutic/Target gene Therapeutic gene
TherapymRNA vaccine
Treatment CVnCoV|CV07050101
PhasePhase2|Phase3
Recruitment statusCompleted
TitleCOVID-19: A Phase 2b/3, Randomized, Observer-Blinded, Placebo-Controlled, Multicenter Clinical Study Evaluating the Efficacy and Safety of Investigational SARS-CoV-2 mRNA Vaccine CVnCoV in Adults 18 Years of Age and Older
Year2020
CountryArgentina|Belgium|Colombia|Dominican Republic|Germany|Mexico|Netherlands|Panama|Peru|Spain
Company sponsorCureVac
Other ID(s)CV-NCOV-004|2020-003998-22
Vector information
Vectorlipid nanoparticle

Clinical Result

Cohort1: CVnCoV Vaccine
Administration route intramuscular injection
Dosage CVnCoV, 12 μg
Pts 19787
Age Adult, Older_Adult
Adverse reactions 17/19787(All-cause mortality); 149/19787(Blood and lymphatic system disorders; Cardiac disorders; Ear and labyrinth disorders; Endocrine disorders; Eye disorders; Gastrointestinal disorders; General disorders; Hepatobiliary disorders; Immune system disorders; Infections and infestations; Injury, poisoning and procedural complications; Metabolism and nutrition disorders; Musculoskeletal and connective tissue disorders; Neoplasms benign, malignant and unspecified(incl cysts and polyps); Nervous system disorders; Pregnancy, puerperium and perinatal conditions; Psychiatric disorders; Renal and urinary disorders; Reproductive system and breast disorders; Respiratory, thoracic and mediastinal disorders; Vascular disorders)
References PMID: 34826381
Cohort2: Placebo
Administration route intramuscular injection
Dosage Placebo, 12 μg
Pts 19753
Age Adult, Older_Adult
Adverse reactions 14/19753(All-cause mortality); 111/19753(Blood and lymphatic system disorders; Cardiac disorders; Ear and labyrinth disorders; Endocrine disorders; Gastrointestinal disorders; General disorders; Hepatobiliary disorders; Immune system disorders; Infections and infestations; Injury, poisoning and procedural complications; Musculoskeletal and connective tissue disorders; Neoplasms benign, malignant and unspecified(incl cysts and polyps); Nervous system disorders; Pregnancy, puerperium and perinatal conditions; Psychiatric disorders; Renal and urinary disorders; Reproductive system and breast disorders; Respiratory, thoracic and mediastinal disorders; Skin and subcutaneous tissue disorders; Vascular disorders)
References PMID: 34826381

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