Basic Information

Gene symbol MAGEA1 Synonyms CT1.1, MAGE1 Type of gene protein-coding
Description MAGE family member A1

GTO ID GTC0536
Trial ID NCT04639245
Disease Breast Cancer | Triple-Receptor Negative Breast Cancer | Lung Non-Small Cell Carcinoma | Lung Cancer | Urothelial Carcinoma
Altered gene MAGE-A1
Therapeutic/Target gene Target gene
TherapyTCR-T cell
Treatment MAGE-A1 TCR-T cells
Co-treatment Atezolizumab
HLAHLA-A*02:01
PhasePhase1|Phase2
Recruitment statusTerminated
TitleATTAMAGE-A1.: Phase I/II Study of Autologous CD8+ and CD4+ Transgenic T Cells Expressing High Affinity MAGE-A1-Specific T-Cell Receptor (TCR) Combined With Atezolizumab in Patients With Metastatic MAGE-A1 Expressing Cancer
Year2020
CountryUnited States
Company sponsorFred Hutchinson Cancer Center
Other ID(s)RG1007463|NCI-2020-06602|10420

Clinical Result

Cohort 1
Administration route infusion
Donor type autologous
Pts 1
Age Adult, Older_Adult
Lymph depletion Yes
Outcome 1/1(SD)
Adverse reactions 1/1(All couse mortality)

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