Basic Information

Gene symbol GPC3 Synonyms DGSX, GTR2-2, MXR7, OCI-5, SDYS, SGB, SGBS, SGBS1 Type of gene protein-coding
Description glypican 3

GTO ID GTC0525
Trial ID NCT04405778
Disease Solid Tumor
Altered gene GPC3
Therapeutic/Target gene Target gene
TherapyCAR-T cell
Treatment TAK-102
PhasePhase1
Recruitment statusActive, Not Recruiting
TitleAn Open-Label, Dose Escalation, Phase 1, First-in-Human Study of TAK-102 in Adult Patients With GPC3-Expressing Previously Treated Solid Tumors
Year2020
CountryJapan
Company sponsorTakeda
Other ID(s)TAK-102-1501|U1111-1247-6429|jRCT1080225204

Clinical Result

Cohort 1
Administration route intravenous infusion
Dosage 1E7 cells, 1E8 cells, 5E8 cells
Donor type autologous
Pts 11
Age Adult, Older_Adult
Lymph depletion Yes
Outcome 5/11(SD)
Adverse reactions Six pts experienced cytokine release syndrome(Grade1: 5 pts, Grade2: 1 pt)
References DOI: 10.1200/JCO.2024.42.16_suppl.2543

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