Basic Information

Gene symbol CTAG1B Synonyms CTAG, ESO1, CT6.1, CTAG1, LAGE-2, LAGE2B, NY-ESO-1 Type of gene protein-coding
Description cancer/testis antigen 1B

GTO ID GTC0521
Trial ID NCT04318964
Disease Synovial Sarcoma | Liposarcoma
Altered gene NY-ESO-1
Therapeutic/Target gene Target gene
TherapyTCR-T cell
Treatment TAEST16001 cells
HLAHLA-A*02:01
PhasePhase1
Recruitment statusActive, Not Recruiting
TitleAn Open, Single Arm and Early Clinical Study of TAEST16001 in the Treatment of Solid Tumor Mainly Containing Soft Tissue Sarcoma With Positive Expression of Tumor Antigen NY-ESO-1 (HLA-A * 02:01)
Year2020
CountryChina
Company sponsorSun Yat-sen University
Other ID(s)SunYat-senU-TAEST16001
Vector information
Vectorlentivirus
Transgene/Inserted geneCTAG1B
Vector production methodTAEST16001 cells were generated from CD14− and CD25-depleted PBMCs by Sepax C-pro and CliniMACS plus. CD14 and CD25 negative cells were activated and expanded using αCD3/αCD28 antibody-conjugated beads in the presence of 200 IU/mL of recombinant IL-2, transduced with a lentivirus at a multiplicity of infection of 1 transducing unit per cell. Cells were expanded for 9-13 days by Wave Bioreactor and then harvested by Sefia and formulated by Sepax C-pro. TCR-T cell product would be frozen for release testing, which took an additional 7-10 days.
Additional featureINF-γ

Clinical Result

Cohort1: synovial sarcoma
Administration route infusion
Dosage 0.51~11.09E9 cells
Donor type autologous
Pts 10
Age Adult, Older_Adult
Lymph depletion Yes
Adverse reactions No TCR-related serious AEs
References PMID: 37586317
Cohort2: liposarcoma
Administration route infusion
Dosage 0.51~11.96E9 cells
Donor type autologous
Pts 2
Age Adult, Older_Adult
Lymph depletion Yes
Adverse reactions No TCR-related serious AEs
References PMID: 37586317

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