Basic Information

Gene symbol CD19 Synonyms B4, CVID3 Type of gene protein-coding
Description CD19 molecule

GTO ID GTC0519
Trial ID NCT04271410
Disease B-Cell Lymphoma | Leukemia | Diffuse Large B-Cell Lymphoma | B-Cell Chronic Lymphocytic Leukemia
Altered gene CD19
Therapeutic/Target gene Target gene
TherapyCAR-T cell
Treatment CD19 CAR-T cells
Generation2nd
PhasePhase1|Phase2
Recruitment statusRecruiting
TitleCD19+Targeted CAR-T Cell Therapy for Relapsed/Refractory CD19+ B Cell Leukemia and Lymphoma
Year2019
CountryChina
Company sponsorChongqing Precision Biotech Co., Ltd
Other ID(s)PBC004
Vector information
Vectorlentivirus
ConstructscFv-4-1BB-CD3ζ

Clinical Result

Cohort 1
Administration route None
Dosage 1E5 cells/kg, 3E5 cells/kg, 1E7 cells
Pts 13
Age Child, Adult, Older_Adult
Lymph depletion Yes
Outcome 13/13(CR)
Adverse reactions 11/13(Grade 1-2 CRS), no ≥ 3 CRS; 1/12(Grade 1 ICANS), no ≥ 2 ICANS
References DOI: 10.1200/JCO.2022.40.16_suppl.7008

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