Basic Information

Gene symbol CD19 Synonyms B4, CVID3 Type of gene protein-coding
Description CD19 molecule

GTO ID GTC0517
Trial ID NCT04257578
Disease Primary Mediastinal B-Cell Lymphoma | Diffuse Large B-Cell Lymphoma | Follicular Lymphoma | Diffuse Large B-Cell Lymphoma Activated B-Cell Type | B-Cell Non-Hodgkin's Lymphoma | High-Grade B-Cell Lymphoma
Altered gene CD19
Therapeutic/Target gene Target gene
TherapyCAR-T cell
Treatment YesCAR-Ta|Axicabtagene Ciloleucel|axi-cel
Co-treatment acalabrutinib
Generation2nd
PhasePhase1|Phase2
Recruitment statusRecruiting
TitleAcalabrutinib and Anti-CD19 CAR T-cell Therapy for the Treatment of B-cell Lymphoma
Year2020
CountryUnited States
Company sponsorUniversity of Washington
Other ID(s)RG1006269|NCI-2020-00238|10418
Vector information
Vectorlentivirus
ConstructscFv-CD28-CD3ζ

Clinical Result

Cohort 1
Administration route intravenous infusion
Donor type Autologous
Pts 14
Age Adult, Older_Adult
Lymph depletion Yes
Outcome 71%(CR,day 30); 93%(ORR,day 30)
Adverse reactions 13/14(CRS); 8/14(ICANS)
References DOI: 10.1182/blood-2023-183034

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