Basic Information

Gene symbol CD19 Synonyms B4, CVID3 Type of gene protein-coding
Description CD19 molecule

GTO ID GTC0516
Trial ID NCT04245839
Disease Non-Hodgkin's Lymphoma
Altered gene CD19
Therapeutic/Target gene Target gene
TherapyCAR-T cell
Treatment Breyanzi|Lisocabtagene maraleucel|liso-cel|JCAR017
Location approved US, Japan, EU, Switzerland, UK, Canada
Generation2nd
PhasePhase2
Recruitment statusRecruiting
TitleA Study to Evaluate the Efficacy and Safety of JCAR017 in Adult Subjects With Relapsed or Refractory Indolent B-cell Non-Hodgkin Lymphoma (NHL)
Year2020
CountryUnited States
Company sponsorCelgene
Other ID(s)JCAR017-FOL-001|U1111-1244-9768|2019-004081-18
Vector information
Vectorlentivirus
ConstructscFv-4-1BB-CD3ζ
Transgene/Inserted geneanti‐CD19 single‐chain variable fragment; 4‐1BB costimulatory motif; CD3ζ T‐cell activation domain

Clinical Result

Cohort1: pts in third line
Administration route intravenous infusion
Dosage 1E8 cells
Donor type Autologous
Pts 101
Age Adult, Older_Adult
Lymph depletion Yes
Outcome 94.1%(CR)
References DOI: 10.1002/hon.3196_LBA4
Cohort2: pts in secondline
Administration route intravenous infusion
Dosage 1E8 cells
Donor type Autologous
Pts 130
Age Adult, Older_Adult
Lymph depletion Yes
Adverse reactions 65%(neutropenia); 58%(Grade 3 CRS); 15%(neurological events)
References DOI: 10.1002/hon.3196_LBA4

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