Basic Information

Gene symbol TNFRSF17 Synonyms BCM, BCMA, CD269, TNFRSF13A Type of gene protein-coding
Description TNF receptor superfamily member 17

Gene symbol CD19 Synonyms B4, CVID3 Type of gene protein-coding
Description CD19 molecule

GTO ID GTC0515
Trial ID NCT04236011
Disease Multiple Myeloma
Altered gene BCMA|CD19
Therapeutic/Target gene Target gene
TherapyCAR-T cell
Treatment GC012F
PhaseEarly_Phase1
Recruitment statusUnknown
TitleBCMA and CD19 Targeted Fast Dual CAR-T for BCMA+ Refractory/Relapsed Multiple Myeloma
Year2020
CountryChina
Company sponsorShanghai Changzheng Hospital
Other ID(s)GBF002

Clinical Result

Cohort 1
Administration route intravenous infusion
Dosage 1E5 cells/kg, 2E5 cells/kg, 3E5 cells/kg
Donor type Autologous
Pts 28
Age Adult, Older_Adult
Lymph depletion Yes
Outcome 21/28(CR)
Adverse reactions 2/28(Grade 3 CRS); no Grade 4/5 CRS and ICANs
References DOI: 10.1200/JCO.2022.40.16_suppl.8005

Relationship Graph

Overview of Knowledge Graph