Basic Information

Gene symbol CD19 Synonyms B4, CVID3 Type of gene protein-coding
Description CD19 molecule

GTO ID GTC0514
Trial ID NCT04225676
Disease Acute Lymphoblastic Leukemia
Altered gene CD19
Therapeutic/Target gene Target gene
TherapyCAR-T cell
Treatment Kymriah|Tisagenlecleucel
Generation2nd
PhasePhase2
Recruitment statusTerminated
TitleStudy of Efficacy and Safety of Reinfusion of Tisagenlecleucel in Pediatric and Young Adult Patients With Acute Lymphoblastic Leukemia (ALL)
Year2020
CountryUnited States
Company sponsorNovartis Pharmaceuticals
Other ID(s)CCTL019BUS03

Clinical Result

Cohort 1
Administration route None
Dosage ≤50kg: 0.2~5E6 cells/kg, >50kg: 0.1~2.5E8 cells
Donor type Autologous
Pts 5
Age Child, Adult
Lymph depletion Yes
Outcome 1/5(CR,28 Days)
Adverse reactions 0/5(All-cause mortality); 3/5(General disorders; Immune system disorders; Nervous system disorders)

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