Basic Information

Gene symbol CD19 Synonyms B4, CVID3 Type of gene protein-coding
Description CD19 molecule

GTO ID GTC0513
Trial ID NCT04213469
Disease B-Cell Lymphoma
Altered gene CD19
Therapeutic/Target gene Target gene
TherapyCAR-T cell
Treatment CD19 CAR-T cells
Generation2nd
PhaseNot Applicable
Recruitment statusCompleted
TitleA Safety and Efficacy Evaluation of PD1-CD19-CART in Patients With Relapse/Refractory B-cell Lymphoma
Year2020
CountryChina
Company sponsorBioray Laboratories
Other ID(s)2019-CAR-00CH1
Vector information
Vectorother
ConstructscFv-4-1BB-CD3ζ
Additional featurePD1

Clinical Result

Cohort 1
Administration route infusion
Dosage 0.56~2.35 E6 cells/kg
Donor type autologous
Pts 8
Age Adult, Older_Adult
Lymph depletion Yes
Outcome 7/8(CR); 1/8(PR)
Adverse reactions 8/8(haematological toxicity events mainly related to the chemotherapy pretreatment)
References PMID: 36045296

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