Basic Information

Gene symbol CD19 Synonyms B4, CVID3 Type of gene protein-coding
Description CD19 molecule

GTO ID GTC0512
Trial ID NCT04206943
Disease Acute Lymphoblastic Leukemia | Non-Hodgkin's Lymphoma
Altered gene CD19
Therapeutic/Target gene Target gene
TherapyCAR-T cell
Treatment ISIKOK 19
Generation2nd
PhasePhase1|Phase2
Recruitment statusUnknown
TitleStudy of CD19 Specific Chimeric Antigen Receptor Positive T Cells (CAR-T) in ALL and NHL
Year2019
CountryTurkey
Company sponsorAcibadem University
Other ID(s)CD19-SP-CAR-T
Vector information
Vectorlentivirus
ConstructscFv-CD28-CD3ζ
Transgene/Inserted genesingle-chain variable fragment (scFv) of an anti-CD19 monoclonal antibody (FMC63); CD8 hinge region; CD28 transmembrane (TM); co-stimulatory domain; CD3z pro-activator signaling domain
Additional featureEGFRt

Clinical Result

Cohort 1
Administration route None
Dosage 4E6 cells/kg, 6E6 cells/kg
Pts 7
Age Child, Adult, Older_Adult
Outcome 2/7(CR); 3/7(PR); 2/7(PD); The toxicity in this study was mild. Grade 2 CRS was noted in 2 patients.Overall response rate: 72%.
Adverse reactions 4/7(CRS, ICANS, pancytopenia)
References PMID: 35848614

Relationship Graph

Overview of Knowledge Graph