Basic Information

Gene symbol TNFRSF17 Synonyms BCM, BCMA, CD269, TNFRSF13A Type of gene protein-coding
Description TNF receptor superfamily member 17

Gene symbol CD19 Synonyms B4, CVID3 Type of gene protein-coding
Description CD19 molecule

GTO ID GTC0511
Trial ID NCT04182581
Disease Multiple Myeloma
Altered gene BCMA|CD19
Therapeutic/Target gene Target gene
TherapyCAR-T cell
Treatment BCMA/CD19 CAR-T cells
PhaseEarly_Phase1
Recruitment statusUnknown
TitleA Study of BCMA/CD19 Dual-Target CAR-T Cell Immunotherapy for Relapsed or Refractory Multiple Myeloma
Year2019
CountryChina
Company sponsorXijing Hospital
Other ID(s)PGC0008

Clinical Result

Cohort 1
Administration route None
Dosage 1E5 cells/kg, 2E5 cells/kg, 3E5 cells/kg
Pts 16
Age Adult, Older_Adult
Outcome 9/16(CR); 15/16(ORR)
Adverse reactions 14/16(Grade 1-2 CRS); 2/16(Grade 3 CRS)
References DOI: 10.1182/blood-2020-138614

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