Basic Information

Gene symbol TNFRSF17 Synonyms BCM, BCMA, CD269, TNFRSF13A Type of gene protein-coding
Description TNF receptor superfamily member 17

GTO ID GTC0510
Trial ID NCT04181827
Disease Multiple Myeloma
Altered gene BCMA
Therapeutic/Target gene Target gene
TherapyCAR-T cell
Treatment Carvykti|Ciltacabtagene Autoleucel|Cilta-cel|JNJ-68284528
Location approved US, EU, UK, Japan, Australia, Canada
Generation2nd
PhasePhase3
Recruitment statusActive, Not Recruiting
TitleA Study Comparing JNJ-68284528, a CAR-T Therapy Directed Against B-cell Maturation Antigen (BCMA), Versus Pomalidomide, Bortezomib and Dexamethasone (PVd) or Daratumumab, Pomalidomide and Dexamethasone (DPd) in Participants With Relapsed and Lenalidomide-Refractory Multiple Myeloma (CARTITUDE-4)
Year2020
CountryUnited States
Company sponsorJanssen Research & Development, LLC
Other ID(s)CR108695|2019-001413-16|68284528MMY3002
Vector information
Vectorlentivirus
ConstructscFv-4-1BB-CD3ζ
Transgene/Inserted geneBCMA-binding single domain; CD3ζ T-cell activation domain; 4-1BB costimulatory domain

Clinical Result

Cohort1: cilta-cel
Administration route intravenous infusion
Dosage 7.1E5 cells/kg
Donor type Autologous
Pts 176
Age Adult, Older_Adult
Lymph depletion Yes
Outcome 65%(CR); 12-month PFS:76%
Adverse reactions 97%(Grade 3/4 AEs); 27%(infections); 94%(cytopenias); 76%(CRS); 5%(ICANS)
References DOI: 10.1200/JCO.2023.41.17_suppl.LBA106
Cohort2: standard-of-care
Administration route None
Donor type Autologous
Pts 208
Age Adult, Older_Adult
Outcome 32%(CR); 12-month PFS:49%
Adverse reactions 94%(Grade 3/4 AEs); 25%(infections); 86%(cytopenias)
References DOI: 10.1200/JCO.2023.41.17_suppl.LBA106

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