Basic Information

Gene symbol CD22 Synonyms SIGLEC-2, SIGLEC2 Type of gene protein-coding
Gene perturbation-related omics dataset PerturbAtlas | PertOrg
Description CD22 molecule

GTO ID GTC0507
Trial ID NCT04163575
Disease Lymphoma | Leukemia
Altered gene CD22
Therapeutic/Target gene Target gene
TherapyCAR-T cell
Treatment CD22 CAR-T cells
PhasePhase1|Phase2
Recruitment statusUnknown
TitleImmunotherapy With CD22 CAR T-cells for B-Cell Lymphoma, ALL and CLL
Year2019
CountryChina
Company sponsorKecellitics Biotech Company Ltd
Other ID(s)Kece-2

Clinical Result

Cohort 1
Administration route None
Donor type Autologous
Pts 97
Age Child, Adult, Older_Adult
Outcome 4-year overall survival:52.64% (95%CI, 28.81-75.85%); leukemia-free survival: 49.86% (95%CI, 27.30-72.45%)
Adverse reactions 4-year relapse incidence:6.78%(95%CI, 3.12-14.77%); 4-year non-relapse mortality:45.00%(95%CI, 26.13-77.50%)
References DOI: 10.1182/blood-2022-166993

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