Basic Information

Gene symbol CD37 Synonyms GP52-40, TSPAN26 Type of gene protein-coding
Description CD37 molecule

GTO ID GTC0504
Trial ID NCT04136275
Disease T-Cell Lymphoma | Non-Hodgkin's Lymphoma | Lymphoma | B-Cell Lymphoma | Leukemia | Hematologic Cancer
Altered gene CD37
Therapeutic/Target gene Target gene
TherapyCAR-T cell
Treatment CAR-37 T cells
Generation2nd
PhasePhase1
Recruitment statusRecruiting
TitleCAR-37 T Cells In Hematologic Malignancies
Year2020
CountryUnited States
Company sponsorMassachusetts General Hospital
Other ID(s)19-087
Vector information
Vectorlentivirus
ConstructscFv-4-1BB-CD3ζ
Additional featureEGFRt

Clinical Result

Cohort 1
Administration route intravenous infusion
Dosage 100~300E6 cells
Donor type Autologous
Pts 4
Age Adult, Older_Adult
Lymph depletion Yes
Outcome 3/4(CR)
Adverse reactions 1/4(Grade 3 CRS and Grade 3 ICANS)

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