Basic Information

Gene symbol CD19 Synonyms B4, CVID3 Type of gene protein-coding
Description CD19 molecule

Gene symbol MS4A1 Synonyms B1, Bp35, CD20, CVID5, FMC7, LEU-16, S7 Type of gene protein-coding
Description membrane spanning 4-domains A1

GTO ID GTC0494
Trial ID NCT04007029
Disease Mantle Cell Lymphoma | Small Lymphocytic Lymphoma | Chronic Lymphocytic Leukemia | Diffuse Large B-Cell Lymphoma | Follicular Lymphoma | Lymphoplasmacytic Lymphoma | Primary Mediastinal B-Cell Lymphoma
Altered gene CD19|CD20
Therapeutic/Target gene Target gene
TherapyCAR-T cell
Treatment CD19/CD20 CAR-T cells
Generation2nd
PhasePhase1
Recruitment statusRecruiting
TitleModified Immune Cells (CD19/CD20 CAR-T Cells) in Treating Patients With Recurrent or Refractory B-Cell Lymphoma or Chronic Lymphocytic Leukemia
Year2019
CountryUnited States
Company sponsorJonsson Comprehensive Cancer Center
Other ID(s)18-001989|NCI-2019-03190|18-001989
Vector information
Vectorlentivirus
ConstructscFv-4-1BB-CD3ζ
Transgene/Inserted geneantibody Leu16 scFv; antibody FMC63 scFv; hinge domain of human IgG4; transmembrane domain of human CD28; cytoplasmic signaling domains of human 4-1BB and CD3ζ
Regulatory elementelongation factor 1 alpha (EF1-α) promoter

Clinical Result

Cohort 1
Administration route None
Dosage 36~165E6 cells
Donor type Autologous
Pts 10
Age Adult, Older_Adult
Lymph depletion Yes
Outcome 7/10(CR); 9/10(ORR)
Adverse reactions no neurotoxicity, maximum grade 1 cytokine release syndrome
References PMID: 36416874

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