Basic Information

Gene symbol CD7 Synonyms GP40, LEU-9, TP41, Tp40 Type of gene protein-coding
Description CD7 molecule

GTO ID GTC0493
Trial ID NCT04004637
Disease T-Cell Childhood Lymphoblastic Lymphoma | Acute Monocytic Leukemia
Altered gene CD7
Therapeutic/Target gene Target gene
TherapyCAR-NK cell|CAR-T cell
Treatment CD7 CAR-T cells
Generation3rd
PhasePhase1
Recruitment statusUnknown
TitleCD7 CAR-T Cells for Patients With R/R CD7+ NK/T Cell Lymphoma, T-lymphoblastic Lymphoma and Acute Lymphocytic Leukemia
Year2019
CountryChina
Company sponsorPersonGen BioTherapeutics (Suzhou) Co., Ltd.
Other ID(s)PG-CART-007-001

Clinical Result

Cohort 1
Administration route None
Dosage 1~1.5E6 cells/kg
Donor type Autologous
Pts 8
Age Child, Adult, Older_Adult
Outcome 7/8(CR); 1/8(PR).87.5% of patients achieved CR between day 14 to month 3, 1 patient has achieved CR for more than 12 months.
Adverse reactions 1/8(grade 4 CRS); 7/8(grade 1 or 2 cytokine release syndrome); no T-cell hypoplasia; no neurologic toxicities
References PMID: 35435984

Relationship Graph

Overview of Knowledge Graph