Basic Information

Gene symbol TNFRSF17 Synonyms BCM, BCMA, CD269, TNFRSF13A Type of gene protein-coding
Description TNF receptor superfamily member 17

GTO ID GTC0489
Trial ID NCT03975907
Disease Multiple Myeloma
Altered gene BCMA
Therapeutic/Target gene Target gene
TherapyCAR-T cell
Treatment CT053|zevorcabtagene autoleucel|zevor-cel
Location approved China
Generation2nd
PhasePhase1|Phase2
Recruitment statusRecruiting
TitleClinical Trial to Evaluate CT053 in Patients With Relapsed and/or Refractory Multiple Myeloma (LUMMICAR STUDY 1)
Year2019
CountryChina
Company sponsorCARsgen Therapeutics Co., Ltd.
Other ID(s)CT053-MM-01

Clinical Result

Cohort 1
Administration route None
Dosage 1E8 cells, 1.5E8 cells
Donor type Autologous
Pts 14
Age Adult, Older_Adult
Lymph depletion Yes
Outcome 5/12(CR); 7/14(PR) at least 4 weeks
Adverse reactions 100%(≥ grade 3 neutropenia); 91.7%(≥ grade 3 thrombocytopenia); No grade 3 or higher CRS or neurotoxicity
References DOI: 10.1182/blood-2023-179667

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