Basic Information

Gene symbol CD19 Synonyms B4, CVID3 Type of gene protein-coding
Description CD19 molecule

GTO ID GTC0483
Trial ID NCT03953599
Disease B-Cell Acute Lymphoblastic Leukemia
Altered gene CD19
Therapeutic/Target gene Target gene
TherapyCAR-T cell
Treatment CD19-STAR-T cells
PhasePhase1
Recruitment statusCompleted
TitleCD19-STAR-T for Patients With B Cell Malignancies
Year2019
CountryChina
Company sponsorHebei Yanda Ludaopei Hospital
Other ID(s)HXYT-003
Vector information
Vectorlentivirus
Transgene/Inserted geneFMC63 scFv; CD8 transmembrane domain; CD3ζ plus 4-1BB signaling chains

Clinical Result

Cohort 1
Administration route infusion
Dosage 0.6~2.5E6 cells
Pts 18
Age Child, Adult, Older_Adult
Lymph depletion Yes
Adverse reactions 10/18(CRS); 2/18(seizures)
References PMID: 35491511

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