Basic Information

Gene symbol MSLN Synonyms MPF, SMRP Type of gene protein-coding
Gene perturbation-related omics dataset PerturbAtlas
Description mesothelin

GTO ID GTC0477
Trial ID NCT03907852
Disease Cholangiocarcinoma | Mesothelioma | Ovarian Cancer
Altered gene Mesothelin
Therapeutic/Target gene Target gene
TherapyTCR-T cell
Treatment Gavocabtagene Autoleucel|Gavo-cel|TC-210
Co-treatment Nivolumab|Ipilimumab
PhasePhase1|Phase2
Recruitment statusRecruiting
TitleA Phase 1/2 Single Arm Open-Label Clinical Trial of Gavocabtagene Autoleucel (Gavo-cel) in Patients With Advanced Mesothelin-Expressing Cancer
Year2019
CountryUnited States
Company sponsorTCR2 Therapeutics
Other ID(s)TCR2-18-01
Vector information
Vectorlentivirus
Transgene/Inserted genehumanized, llama-derived, single-domain anti-mesothelin antibody MH1; human CD3ε subunit

Clinical Result

Cohort 1
Administration route infusion
Dosage 0.5~5E8 cells
Donor type autologous
Pts 32
Age Adult, Older_Adult
Lymph depletion No
Adverse reactions 5/32(pneumonia); 8/32(CRS); 2/32(pleuritis); 1/32(pericarditis); 1/32(peritonitis); 1/32(respiratory failure)
References PMID: 37501016

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