Basic Information

Gene symbol CD19 Synonyms B4, CVID3 Type of gene protein-coding
Description CD19 molecule

GTO ID GTC0475
Trial ID NCT03902197
Disease Acute Lymphoblastic Leukemia
Altered gene CD19
Therapeutic/Target gene Target gene
TherapyCAR-T cell
Treatment CD19 hsCAR-T
Generation2nd
PhasePhase2
Recruitment statusRecruiting
TitleCD19 hsCAR-T for Refractory/Relapsed CD19+ B-ALL Patients
Year2019
CountryChina
Company sponsorXuanwu Hospital, Beijing
Other ID(s)CD19hsCAR20190401
Vector information
Vectorlentivirus
ConstructscFv-4-1BB-CD3ζ|scFv-CD28-CD3ζ
Vector production methodPBMCs from the donor were collected by leukapheresis. CD3-positive T lymphocytes were enriched and activated by using CD3/CD28 magnetic beads. Activated T cells were transduced with lentivirus expressing CD19hsCAR, and were stimulated by SmAb during the expansion stage in vitro. CD19hsCAR-T cells were harvested and cryopreserved after a 10-day culture.

Clinical Result

Cohort 1
Administration route intravenous infusion
Dosage 1E5 cells/kg, 4E6 cells/kg
Donor type Allogeneic
Pts 1
Age Child, Adult, Older_Adult
Outcome 1/1(CR), remained for around 8 months
References PMID: 33424835

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