Basic Information


GTO ID GTC0474
Trial ID NCT03899415
Disease Hepatocellular Carcinoma
Altered gene HBV gene
Therapeutic/Target gene Target gene
TherapyTCR-T cell
Treatment HBV TCR-T cells
HLAHLA-A*02:01|HLA-CW*08:01
PhasePhase1
Recruitment statusRecruiting
TitleTCR-Redirected T Cells Therapy in Patient With HBV Related HCC
Year2019
CountryChina
Company sponsorBeijing 302 Hospital
Other ID(s)LTCR-HCC-3-1
Vector information
Vectorelectroporation

Clinical Result

Cohort 1
Administration route infusion
Dosage 0.1~50E5 cells
Donor type autologous
Pts 8
Age Adult, Older_Adult
Lymph depletion No
Outcome 1/8(PR) ; 3/8(SD); 2/8(PD)
Adverse reactions 2/8(elevation of liver enzymes); 1/8(jaundice)
References PMID: 34850325

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