Basic Information

Gene symbol CD19 Synonyms B4, CVID3 Type of gene protein-coding
Description CD19 molecule

GTO ID GTC0473
Trial ID NCT03896854
Disease Acute Myeloid Leukemia
Altered gene CD19
Therapeutic/Target gene Target gene
TherapyCAR-T cell
Treatment CD19 CAR-T cells
Generation2nd
PhasePhase1|Phase2
Recruitment statusRecruiting
TitleCART-19 T Cell in CD19 Positive Relapsed or Refractory Acute Myeloid Leukemia (AML)
Year2017
CountryChina
Company sponsorShanghai Unicar-Therapy Bio-medicine Technology Co., Ltd
Other ID(s)UnicarTherapy20190308

Clinical Result

Cohort 1
Administration route intravenous infusion
Dosage 1~20E6 cells/kg
Pts 11
Age Child, Adult, Older_Adult
Lymph depletion Yes
Outcome 10/11(CR, 1 month)
Adverse reactions 3/11(cytokine release syndrome)
References PMID: 33627797

Relationship Graph

Overview of Knowledge Graph