Basic Information

Gene symbol CD19 Synonyms B4, CVID3 Type of gene protein-coding
Description CD19 molecule

Gene symbol MS4A1 Synonyms B1, Bp35, CD20, CVID5, FMC7, LEU-16, S7 Type of gene protein-coding
Description membrane spanning 4-domains A1

GTO ID GTC0472
Trial ID NCT03870945
Disease B-Cell Non-Hodgkin's Lymphoma
Altered gene CD19|CD20
Therapeutic/Target gene Target gene
TherapyCAR-T cell
Treatment Zamtocabtagene Autoleucel|MB-CART2019.1
PhasePhase1|Phase2
Recruitment statusActive, Not Recruiting
TitleSafety of MB-CART2019.1 in Lymphoma Patients (MB-CART2019.1 Lymphoma / DALY 1)
Year2019
CountryGermany
Company sponsorMiltenyi Biomedicine GmbH
Other ID(s)M-2018-331
Vector information
Vectorlentivirus

Clinical Result

Cohort1: dose level 1
Administration route intravenous infusion
Dosage 1E6 cells/kg
Donor type Autologous
Pts 6
Age Adult, Older_Adult
Outcome 3/6(PR)
Adverse reactions no any CAR-T-related severe events
References DOI: 10.1182/blood-2020-136067
Cohort2: dose level 2
Administration route intravenous infusion
Dosage 2.5E6 cells/kg
Donor type Autologous
Pts 6
Age Adult, Older_Adult
Outcome 6/6(PR)
Adverse reactions no any CAR-T-related severe events
References DOI: 10.1182/blood-2020-136067

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