Basic Information

Gene symbol CD4 Synonyms CD4mut, IMD79, Leu-3, OKT4D, T4 Type of gene protein-coding
Description CD4 molecule

GTO ID GTC0467
Trial ID NCT03829540
Disease T-Cell Lymphoblastic Leukemia | Lymphoma
Altered gene CD4
Therapeutic/Target gene Target gene
TherapyCAR-T cell
Treatment CD4 CAR-T cells
Generation3rd
PhasePhase1
Recruitment statusRecruiting
TitleCD4CAR for CD4+ Leukemia and Lymphoma
Year2019
CountryUnited States
Company sponsorIndiana University
Other ID(s)CTO-IUSCCC-ICG122-101|FD-R-006820-01
Vector information
Vectorlentivirus
ConstructscFv-CD28-4-1BB-CD3ζ
Transgene/Inserted geneCD28 transmembrane and cytoplasmic domains; co-stimulatory 4-1BB intracellular TRAF binding domain; CD3z chain intracellular domain

Clinical Result

Cohort 1
Administration route None
Dosage 8E5 cells
Donor type Autologous
Pts 3
Age Adult, Older_Adult
Lymph depletion Yes
Outcome 2/3(CR); 1/3(SD)
Adverse reactions lymphopenia
References DOI: 10.1182/blood-2023-180111

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