| Viral genome modification | ET190L1-TCR fuses the Fab fragment of ET190L1 with the C-terminal signaling domain of a γ/δ TCR, which is derived from the human TCR γ constant chain (UniProtKB-P0CF51) and δ constant chain (UniProtKB-B7Z8K6). The heavy chain domain of the Fab fragment is fused to the δ chain, and the light chain domain is fused to the γ chain. Moreover, an independent chimeric molecule consisting of the scFv of ET190L1 and the CD28 transmembrane and intracellular domain is added to further promote T cell activation. |